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Topical calcineurin inhibitors (TCIs) were developed following research on immunosuppressive drugs used orally for their anti-rejection effect in transplanted patients. They are used as an alternative to topical corticosteroids for the treatment of inflammatory skin diseases. Two products are available on the market:
– Tacrolimus, marketed in France in 2003 under the name Protopic®
– Pimecrolimus, marketed under the name of Elidel® (did not receive marketing authorization in France).
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