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Syphilis is a sexually transmitted infection caused by a spirochete bacterium: Treponema pallidum. The clinical features are polymorphous and vary depending on the stage of progression. The diagnosis is made by using dark-field microscopy for direct examination to demonstrate T. pallidum in secreted material from erosive or ulcerous and necrotic lesions of the skin or mucosa, on nucleic acid amplification tests (NAT) for T. pallidum or on serological testing.
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