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Therapeutics in Dermatology
A reference textbook in dermatology
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Grover disease

26 August 2015, by DEVEZA E. & AUBIN F.

Transient acantholytic dermatosis (TAD) was first described by Grover in 1970. TAD is a self-limited, transient, primary, nonfamilial, non–immune-mediated acantholytic skin disorder. Grover disease manifests as pruritic, discrete, edematous papules and/or a vesiculopapular rash on the upper trunk (anterior face or interscapular area) of an older white male. The rash begins as a sudden onset of small papules and fragile vesicles, which can quickly form crusts and keratotic erosions. The extremities are usually spared. There is often pruritus that varies in intensity. Lesions progress by flare-ups, resolving spontaneously after several weeks or months leaving no sequelae, and they can recur throughout the years [3, 4, 7].

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