You use Therapeutics in Dermatology on a regular basis and you are pleased with it?

Then help us improve it by

   making a donation here!



MENU
Therapeutics in Dermatology
A reference textbook in dermatology
 You are visiting a Fondation René Touraine website.    Donate English Français

  Health professionals

Home > English > Book > Diseases >

Acrodermatitis enteropathica

23 February 2015, by KHARFI M. & KÜRY S.

Acrodermatitis enteropathica (AEZ; MIM 201100) is a rare hereditary illness of autosomal recessive transmission that is linked to a zinc absorption abnormality in the intestinal mucosa.

In 2002, the gene SLC39A4 (solute carrier family 39 member 4) for the zinc transporter protein ZIP4 was identified as causing this condition. It is located at chromosome 8q24 [1-3].

Acrodermatitis enteropathica (AE) normally presents when infants are weaned from breastmilk. It is characterised by a stereotypical and highly suggestive clinical picture, combining predominantly periorificial and acral skin lesions, chronic diarrhoea and psychiatric symptoms. This diagnosis is easily confirmed by demonstrating low serum levels of zinc [4-6].

× N.B. : This limited content is for the general public. If you are a health professional, click here to register for free and gain access to a dedicated deeper content.
If you already have an account, log in!

Follow us

Newsletter

René Touraine Foundation