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Therapeutics in Dermatology
A reference textbook in dermatology
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  Health professionals

1 - METHOD OF ACTION

Etanercept (Enbrel®) is a biotherapy belonging to the anti-TNF alpha family. Contrary to the other anti-TNF alpha drugs which are monoclonal antibodies, etanercept is a fusion protein. The soluble P75 TNF alpha receptor is linked to the Fc portion of a human IgG1. Etanercept binds to the soluble TNF alpha receptor competitively, preventing it from binding to its target receptors. 

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