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Therapeutics in Dermatology
A reference textbook in dermatology

Porokeratoses

4 March 2014, by KANITAKIS J.

1 - GENERAL OVERVIEW

The term “Porokeratosis” (PK) encompasses a group of relatively uncommon dermatoses that may be acquired or genetic and that are characterised by a keratinisation defect of the epidermis of unknown origin. Clinically, the lesions present as annular or linear, more or less atrophic plaques with a well-defined, keratotic, ridge-like border; histologically, all PK forms are characterized by the presence of a “cornoid lamella”, a vertical stack of parakeratotic corneocytes embedded within the orthokeratotic stratum corneum, overlying an epidermal invagination that displays loss of the granular layer [1].

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