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Therapeutics in Dermatology
A reference textbook in dermatology
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  Health professionals

1 - MECHANISM OF ACTION

Adalimumab (Humira®) is a recombinant human monoclonal antibody that inhibits TNF-α.

TNF-alpha, a molecule that promotes inflammation, plays a key role in chronic inflammatory diseases. Humira® is an antibody that binds specifically to TNF-α, which stops the molecule from binding to its natural receptor. Humira® therefore stops TNF-α from exerting its anti-inflammatory effect. Although in principle Humira® is only mildly immunogenic, anti-adalimumab antibodies are observed in 8 to 10% of patients [1].

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